Spexin

Spexin (Neuropeptide Q) is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin can function through both central and peripheral actions. Spexin upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents) . Spexin improves cardiac function in the Doxorubicin hydrochloride (HY-15142) -induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy[1][2][3].

Product Specifications

CAS Number

[1370290-58-6]

Product Name Alternative

Neuropeptide Q

UNSPSC

12352209

Target

Apoptosis; Autophagy; Ferroptosis; Neuropeptide Y Receptor

Type

Peptides

Related Pathways

Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/spexin.html

Purity

99.94

Solubility

H2O : 25 mg/mL (ultrasonic)

Smiles

O=C(N1[C@@H](CCC1)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](CCSC)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(NCC(N[C@@H](C)C(N[C@H](C(N)=O)CCC(N)=O)=O)=O)=O)=O)=O)CC2=CC=C(C=C2)O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)NC([C@@H](NC([C@@H](N)CC(N)=O)=O)CC3=CNC4=CC=CC=C34)=O

Molecular Formula

C74H114N20O19S

Molecular Weight

1619.88

References & Citations

[1]Porzionato A, et al. Spexin expression in normal rat tissues. J Histochem Cytochem. 2010;58 (9) :825-837.|[2]Ou W, et al. Spexin inhibits excessive autophagy-induced ferroptosis to alleviate doxorubicin-induced cardiotoxicity by upregulating Beclin 1. Br J Pharmacol. 2024 Nov;181 (21) :4195-4213.|[3]Walewski JL, et al. Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity. Obesity (Silver Spring) . 2014 Jul;22 (7) :1643-52.