RepSox

RepSox (E-616452) is a potent and selective transforming growth factor-beta receptor I/activin like kinase 5 (TGF-β-RI/ALK5) inhibitor. RepSox inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox can be used for the research of obesity and associated metabolic diseases such as type 2 diabetes[1][2].

Product Specifications

CAS Number

[446859-33-2]

Product Name Alternative

E-616452; SJN 2511

UNSPSC

12352005

Hazard Statement

H301

Target

Organoid; TGF-β Receptor

Type

Reference compound

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/RepSox.html

Purity

99.92

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

CC1=NC(C2=NNC=C2C3=NC4=CC=CN=C4C=C3)=CC=C1

Molecular Formula

C17H13N5

Molecular Weight

287.32

Precautions

H301

References & Citations

[1]Gellibert F, et al. Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem. 2004 Aug 26;47 (18) :4494-506.|[2]Wan-Zhi Tu, et al. RepSox, a small molecule inhibitor of the TGFβ receptor, induces brown adipogenesis and browning of white adipocytes. Acta Pharmacol Sin. 2019 Dec;40 (12) :1523-1531.