LXQ46
Product Specifications
UNSPSC Description
LXQ46 is an orally active inhibitor for protein tyrosine phosphatase 1B (PTP1B), with an IC50 of 0.190 μM. LXQ46 enhances insulin and leptin signaling pathways in insulin-resistant C2C12. LXQ46 ameliorates type 2 diabetes and increases insulin tolerance in mouse models[1].
Target Antigen
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/lxq46.html
Smiles
BrC1=C(O)C(O)=CC(C2=NC=C(C3=CC=C(OC4=CC=C(C=C4)OCC)C=C3)O2)=C1Br
Molecular Weight
547.19
References & Citations
[1]Li X, et al., Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors. Eur J Med Chem. 2019 Mar 15;166:178-185.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-160514/LXQ46-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-160514/
Clinical Information
No Development Reported
CAS Number
2097148-94-0
Curated Selection
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