Recombinant SARS-CoV-2 S-trimer Protein (BA.2.86, C-6His)

Recombinant SARS-CoV-2 S-trimer Protein is produced by our Mammalian expression system and the target gene encoding Gln14-Gln1208 is expressed with a 6His tag at C-terminus.Ins16 MPLF, T19I, R21T, LPP24-26 del, A27S, S50L, HV69-70 del, V127F, G142D, Y144 del, F157S, R158G, N211 del, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, N460K, S477N, T478K, N481K, V483 del, E484K, F486P, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, I670V, N679K, P681R, N764K, S939F, Q954H, N969K and P1143L mutations were identified in the SARS-CoV-2 Omicron variant (known as BA.2.86 lineage) . Six proline substitutions and furin cleavage site substitutions are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively.