RMC-0331

RMC-0331 (RM-023) is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction[1].

Product Specifications

CAS Number

[2488788-52-7]

Product Name Alternative

RM-023

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Ras; SHP2; SOS1

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rmc-0331.html

Concentration

10mM

Purity

98.96

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(N1CC2=NC(Cl)=NC(N[C@@H](C3=CC(C(F)(F)F)=CC(N)=C3)C)=C2C1)C4(OC)CCOCC4

Molecular Formula

C22H25ClF3N5O3

Molecular Weight

499.91

Precautions

H315, H319

References & Citations

[1]Andreas Buckl, et al. Discovery of a Potent, Selective and Orally Bioavailable SOS1 Inhibitor, RMC-0331 (RM-023), an in vivo Tool Compound that Blocks RAS Activation via Disruption of the RAS-SOS1 Interaction.