Nelivaptan

Nelivaptan (SSR-149415) is a selective and orally active vasopressin V1b receptor antagonist (Ki: 3.7 and 1.3 nM for native and recombinant rat V1b receptors, respectively) . Nelivaptan inhibits arginine vasopressin (AVP) -induced Ca2+ increase and corticotropin secretion. Nelivaptan can be used for research of stress, anxiety and depression[1][2].

Product Specifications

CAS Number

[439687-69-1]

Product Name Alternative

SSR-149415

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Vasopressin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/nelivaptan.html

Concentration

10mM

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(N(C(C=C1)=C2C=C1Cl)C([C@@]2(C3=CC=CC=C3OC)N4[C@@H](C[C@@H](O)C4)C(N(C)C)=O)=O)(C(C(OC)=C5)=CC=C5OC)=O

Molecular Formula

C30H32ClN3O8S

Molecular Weight

630.11

Precautions

H302, H315, H319

References & Citations

[1]Serradeil-Le Gal C, et al. Characterization of (2S,4R) -1-[5-chloro-1-[ (2,4-dimethoxyphenyl) sulfonyl]-3- (2-methoxy-phenyl) -2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N, N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a selective and orally active vasopressin V1b receptor antagonist. J Pharmacol Exp Ther. 2002 Mar;300 (3) :1122-30.|[2]Bessa JM, et al. The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling. Mol Psychiatry. 2009 Aug;14 (8) :764-73, 739.