NSC59984

NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway[1]. NSC59984 acts by targeting GOF-mutant p53 and stimulates p73 to restore the p53 pathway signaling[2].

Product Specifications

CAS Number

[803647-40-7]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/NSC59984.html

Concentration

10mM

Purity

99.43

Solubility

DMSO : ≥ 38 mg/mL

Smiles

O=C(N1CCN(C)CC1)/C=C/C2=CC=C([N+]([O-])=O)O2

Molecular Formula

C12H15N3O4

Molecular Weight

265.27

Precautions

H315, H319, H335

References & Citations

[1]Zhang S, et al. Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53. Cancer Res. 2015 Sep 15;75 (18) :3842-52.|[2]Zhang S, et al. Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects againstColorectal Cancer via p73 Activation and Degradation of Mutant p53. Cancer Res. 2015 Sep 15;75 (18) :3842-52.