FICZ

FICZ is a potent aryl hydrocarbon receptor (AhR) agonist with a Kd of 70 pM.

Product Specifications

CAS Number

[172922-91-7]

Product Name Alternative

6-Formylindolo[3,2-b]carbazole

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Aryl Hydrocarbon Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/FICZ.html

Purity

99.42

Solubility

DMSO : 10 mg/mL (ultrasonic; warming)

Smiles

O=CC1=C2C(NC3=C2C=CC=C3)=CC4=C1NC5=C4C=CC=C5

Molecular Formula

C19H12N2O

Molecular Weight

284.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Mohammadi-Bardbori A, et al. The highly bioactive molecule and signal substance 6-formylindolo[3,2-b]carbazole (FICZ) plays bi-functional roles in cell growth and apoptosis in vitro. Arch Toxicol. 2017 Mar 13|[2]Farmahin R, et al. Time-dependent transcriptomic and biochemical responses of 6-formylindolo[3,2-b]carbazole (FICZ) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are explained by AHR activation time. Biochem Pharmacol. 2016 Sep 1;115:134-43|[3]Smith BW, et al. Genome Editing of the CYP1A1 Locus in iPSCs as a Platform to Map AHR Expression throughout Human Development. Stem Cells Int. 2016;2016:2574152.|[4]Wincent E, et al. Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner. Biochem Pharmacol. 2016 Jun 15;110-111:117-29.|[5]N A Davarinos, et al. Aryl Hydrocarbon Receptor Imported Into the Nucleus Following Ligand Binding Is Rapidly Degraded via the Cytosplasmic Proteasome Following Nuclear Export. J Biol Chem. 1999 Oct 1;274 (40) :28708-15.|[6]Riccardo Sibilano, et al. The Aryl Hydrocarbon Receptor Modulates Acute and Late Mast Cell Responses. J Immunol. 2012 Jul 1;189 (1) :120-7.