Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

FICZ

Product Specifications

Product Name Alternative

6-Formylindolo[3,2-b]carbazole

UNSPSC Description

FICZ is a potent aryl hydrocarbon receptor (AhR) agonist with a Kd of 70 pM.

Target Antigen

Aryl Hydrocarbon Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/FICZ.html

Purity

99.42

Solubility

DMSO : 10 mg/mL (ultrasonic;warming)

Smiles

O=CC1=C2C(NC3=C2C=CC=C3)=CC4=C1NC5=C4C=CC=C5

Molecular Weight

284.31

References & Citations

[1]Mohammadi-Bardbori A, et al. The highly bioactive molecule and signal substance 6-formylindolo[3,2-b]carbazole (FICZ) plays bi-functional roles in cell growth and apoptosis in vitro. Arch Toxicol. 2017 Mar 13|[2]Farmahin R, et al. Time-dependent transcriptomic and biochemical responses of 6-formylindolo[3,2-b]carbazole (FICZ) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are explained by AHR activation time. Biochem Pharmacol. 2016 Sep 1;115:134-43|[3]Smith BW, et al. Genome Editing of the CYP1A1 Locus in iPSCs as a Platform to Map AHR Expression throughout Human Development. Stem Cells Int. 2016;2016:2574152.|[4]Wincent E, et al. Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner. Biochem Pharmacol. 2016 Jun 15;110-111:117-29.|[5]N A Davarinos, et al. Aryl Hydrocarbon Receptor Imported Into the Nucleus Following Ligand Binding Is Rapidly Degraded via the Cytosplasmic Proteasome Following Nuclear Export. J Biol Chem. 1999 Oct 1;274(40):28708-15.|[6]Riccardo Sibilano, et al. The Aryl Hydrocarbon Receptor Modulates Acute and Late Mast Cell Responses. J Immunol. 2012 Jul 1;189(1):120-7.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-12451/FICZ-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-12451/FICZ-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

172922-91-7

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

β-Mercaptoethanol
sc-202966 250 mL

β-Mercaptoethanol

Ask
View Details
Human hsa-miR-6503-3p miRNA Antagomir
abx887239-01 10 nmol

Human hsa-miR-6503-3p miRNA Antagomir

Ask
View Details
Human hsa-miR-6503-3p miRNA Antagomir
abx887239-02 20 nmol

Human hsa-miR-6503-3p miRNA Antagomir

Ask
View Details
PE/Cy5 Anti-human CD30 Antibody *MEM-268*
103001N0-AAT 25 Tests

PE/Cy5 Anti-human CD30 Antibody *MEM-268*

Ask
View Details
Recombinant Staphylococcus aureus 3-oxoacyl-[acyl-carrier-protein] synthase 3 (fabH)
MBS1284570-01 0.02 mg (E-Coli)

Recombinant Staphylococcus aureus 3-oxoacyl-[acyl-carrier-protein] synthase 3 (fabH)

Ask
View Details
Recombinant Staphylococcus aureus 3-oxoacyl-[acyl-carrier-protein] synthase 3 (fabH)
MBS1284570-02 0.02 mg (Yeast)

Recombinant Staphylococcus aureus 3-oxoacyl-[acyl-carrier-protein] synthase 3 (fabH)

Ask
View Details