(E)-4-Hydroxycrotonic acid
Product Specifications
UNSPSC Description
(E)-4-Hydroxycrotonic acid (T-HCA) is a high-affinity ligand for GHB binding sites, with a ki value of 1.1 μM. The introduction of diaryl substituents into (E)-4-Hydroxycrotonic acid significantly enhances its affinity for GHB binding sites, with ki values ranging from 0.023 to 0.075 μM. (E)-4-Hydroxycrotonic acid holds promise for optimizing GHB ligand structures and assisting in the development of effective three-dimensional pharmacophore models[1].
Target Antigen
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/e-4-hydroxycrotonic-acid.html
Purity
95.0
Smiles
O=C(O)/C=C/CO
Molecular Weight
102.09
References & Citations
[1]Krall J, et al. Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs. J Med Chem. 2017 Nov 9;60(21):9022-9039.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100982/E-4-Hydroxycrotonic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100982/
Clinical Information
No Development Reported
CAS Number
24587-49-3
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
