2,8-Dihydroxyadenine
2,8-Dihydroxyadenine, an endogenous metabolite, can cause the formation of urinary crystals and kidney stones. 2,8-Dihydroxyadenine can be used to diagnose adenine phosphoribosyltransferase (APRT) deficiency[1][2].
Product Specifications
CAS Number
[30377-37-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/2-8-dihydroxyadenine.html
Purity
98.53
Solubility
H2O : 2.2 mg/mL (ultrasonic; warming)
Smiles
O=C1NC2=C(NC(N2)=O)C(N)=N1
Molecular Formula
C5H5N5O2
Molecular Weight
167.13
Precautions
H302, H315, H319, H335
References & Citations
[1]Ceballos-Picot I, et, al. 2,8-Dihydroxyadenine urolithiasis: a not so rare inborn error of purine metabolism. Nucleosides Nucleotides Nucleic Acids. 2014;33 (4-6) :241-52.|[2]Sreejith P, et, al. 2, 8 Dihydroxyadenine urolithiasis: A case report and review of literature. Indian J Nephrol. 2009 Jan;19 (1) :34-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
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