CVN424
Product Specifications
UNSPSC Description
CVN424 is an orally active and selective GPR6 inverse agonist with a Ki of 9.4 nM and an EC50 of 38 nM. CVN424 is brain-penetrant and has the potential for Parkinson disease research[1][2].
Target Antigen
GPR6
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cvn424.html
Smiles
FC1=C(OC2CCN(C3=NC4=C(N=C3N[C@H]5COCC5)CN(CC4)C(C)=O)CC2)C=CC(F)=C1
Molecular Weight
473.52
References & Citations
[1]Huikai Sun, et al. First-Time Disclosure of CVN424, a Potent and Selective GPR6 Inverse Agonist for the Treatment of Parkinson's Disease: Discovery, Pharmacological Validation, and Identification of a Clinical Candidate. J Med Chem. 2021 Apr 16.|[2]Nicola L Brice, et al. Development of CVN424: A Selective and Novel GPR6 Inverse Agonist Effective in Models of Parkinson Disease. J Pharmacol Exp Ther. 2021 Jun;377(3):407-416.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-134661A/CVN424-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-134661A/CVN424-SDS-MedChemExpress.pdf
CAS Number
2254706-21-1
Available Sizes
Curated Selection
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