Ub4ix

Ub4ix is a DUB/26S proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC50 value of 1.6 μM[1][2].

Product Specifications

CAS Number

[2396736-46-0]

UNSPSC

12352209

Target

Apoptosis; Deubiquitinase; Proteasome

Type

Peptides

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ub4ix.html

Purity

99.32

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC(CSC[C@H](NC([C@](NC1=O)([H])[C@@H](C)CC)=O)C(NCC(N)=O)=O)=O)CC2=CNC3=CC=CC=C23)=O)CC(C)C)=O)CC4=CC=C(C=C4)O)=O)CC(C)C)=O)CC(O)=O)=O)CC(O)=O)=O)CO)=O)=O)CC(O)=O)=O)CC5=CNC6=CC=CC=C56)N[C@H]1CC7=CNC8=CC=CC=C78

Molecular Formula

C84H106N18O23S

Molecular Weight

1767.91

References & Citations

[1]Nawatha M, et al. De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains. Nat Chem. 2019 Jul;11 (7) :644-652. |[2]Saha A, et al. Combining Chemical Protein Synthesis and Random Nonstandard Peptides Integrated Discovery for Modulating Biological Processes. Acc Chem Res. 2023 Jul 18;56 (14) :1953-1965.