Acetaminophen
Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent.[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4]. Acetaminophen induces ferroptosis and leads to acute liver injury in mice model[5].
Product Specifications
CAS Number
[103-90-2]
Product Name Alternative
Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide
UNSPSC
12352005
Hazard Statement
H302
Target
Bacterial; COX; Endogenous Metabolite; Ferroptosis; Histone Acetyltransferase; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/acetaminophen.html
Purity
99.98
Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)
Smiles
O=C(C)NC1=CC=C(O)C=C1
Molecular Formula
C8H9NO2
Molecular Weight
151.16
Precautions
H302
References & Citations
[1]Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22 (2) : p. 383-90.|[2]Miroslav Dinić, et al. Lactobacillus fermentum Postbiotic-induced Autophagy as Potential Approach for Treatment ofAcetaminophen Hepatotoxicity. Front Microbiol. 2017 Apr 6;8:594.|[3]Uchida NS, et al. Hepatoprotective Effect of Citral on Acetaminophen-Induced Liver Toxicity in Mice. Evid Based Complement Alternat Med. 2017;2017:1796209.|[4]Rothen JP, et al. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec;8 (6) :553-9.|[5]An Y, et al., Abietic acid inhibits acetaminophen-induced liver injury by alleviating inflammation and ferroptosis through regulating Nrf2/HO-1 axis. Int Immunopharmacol. 2023 May;118:110029.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
COX-1; COX-2
Citation 01
Acta Pharm Sin B. 2025 Sep 19.|Antioxidants (Basel) . 2023 Jan 9;12 (1) :158.|Appl Microbiol Biotechnol. 2018 Feb;102 (3) :1443-1453.|Appl Microbiol Biotechnol. 2020 Jul;104 (13) :5889-5898.|Basic Clin Pharmacol Toxicol. 2023 Apr;132 (4) :343-353.|Biochem Biophys Res Commun. 2025 Jan 20:749:151365.|Biomed Pharmacother. 2025 Sep 17:192:118569.|Bioorg Chem. 2020 Mar;96:103630.|BMC Microbiol. 2025 Feb 25;25 (1) :87.|Braz J Med Biol Res. 2022 Oct 17;55:e12040.|Cell Biol Toxicol. 2024 Jan 22;40 (1) :1.|Cell Death Dis. 2021 Jan 4;12 (1) :3.|Cell Discov. 2025 Feb 18;11 (1) :15.|Cell Mol Life Sci. 2024 Jul 13;81 (1) :299.|Cell Regen. 2023 Mar 3;12 (1) :6.|Cell Rep Med. 2025 Apr 15;6 (4) :102033.|Cell Res. 2025 Mar;35 (3) :165-185.|Cell. 2023 Dec 7;186 (25) :5500-5516.e21.|Chemosphere. 2019 Jun:225:378-387.|Environ Sci Pollut Res Int. 2017 Feb;24 (6) :5918-5932.|Evid Based Complement Alternat Med. 2020 Nov 19;2020:2696432.|Food Chem Toxicol. 2024 Sep 18:115016.|Food Funct. 2024 May 7;15 (9) :4954-4969.|Free Radic Biol Med. 2024 Jun 19:S0891-5849 (24) 00531-8.|Free Radic Biol Med. 2025 Oct 30:242:275-287.|Front Pharmacol. 2017 Sep 19:8:653.|Institute of Chemistry, Federal University of Rio Grande do Sul (UFRGS) . 2017 Nov.|Int Immunopharmacol. 2025 Mar 29:154:114490.|Int J Mol Sci. 2022 Dec 30;24 (1) :650.|Int J Mol Sci. 2023 Jul 29;24 (15) :12180.|J Appl Toxicol. 2024 Oct;44 (10) :1528-1539.|J Cell Physiol. 2020 Apr;235 (4) :3329-3339.|J Ethnopharmacol. 2023 Oct 28:315:116664.|J Ethnopharmacol. 2025 Mar 26:344:119562.|J Funct Foods. 2020, 104155.|JCI Insight. 2022 Aug 8;7 (15) :e160247.|JCI Insight. 2024 Jan 23;9 (2) :e172632.|JHEP Rep. 2022 Jul 20;4 (10) :100545.|Lab Chip. 2018 Nov 6;18 (22) :3379-3392.|Lab Chip. 2025 Jul 23;25 (15) :3694-3706.|Life Sci. 2024 Aug 13:122968.|Microb Biotechnol. 2025 Jan;18 (1) :e70083.|Mol Biomed. 2025 Oct 10;6 (1) :78.|Molecules. 2018 Dec 29;24 (1) . pii: E110.|Nat Chem Biol. 2025 Aug;21 (8) :1283-1291.|Nat Commun. 2021 Aug 26;12 (1) :5131.|Nat Commun. 2021 May 17;12 (1) :2863.|Nat Commun. 2021 Sep 20;12 (1) :5548.|Nat Commun. 2025 Jan 31;16 (1) :1233.|Pharm Biol. 2022 Dec;60 (1) :958-967.|Phytomedicine. 2022 Sep:104:154337.|PLoS One. 2025 Aug 14;20 (8) :e0329837.|Ren Fail. 2024 Dec;46 (1) :2330629.|Research Square Preprint. 2024 Mar 20.|Results Chem. 2024 Oct.|Sci China Life Sci. 2025 Jul 8.|Small. 2025 Oct 14:e05653.|SSRN. 2023 Apr 18.|Theranostics. 2017 Sep 26;7 (17) :4135-4148.|Toxicology. 2022 Oct:480:153336.|World J Hepatol. 2024 Oct 27;16 (10) :1188-1198.|World J Hepatol. 2025 Mar 27;17 (3) :104520.|Cell Regen. 2025 Oct 16;14 (1) :41.
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