Raloxifene

Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM) . Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research[1].

Product Specifications

CAS Number

[84449-90-1]

Product Name Alternative

Keoxifene; LY156758 (free base) ; LY139481

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/raloxifene.html

Purity

99.62

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=C(C2=CC=C(O)C=C2)SC3=CC(O)=CC=C31)C4=CC=C(OCCN5CCCCC5)C=C4

Molecular Formula

C28H27NO4S

Molecular Weight

473.58

Precautions

H302, H312, H332

References & Citations

[1]Khovidhunkit W, et al. Clinical effects of raloxifene hydrochloride in women. Ann Intern Med. 1999;130 (5) :431-439.|[2]Xu H, et al. Effect of caffeine on ovariectomy-induced osteoporosis in rats. Biomed Pharmacother. 2019;112:108650.