NV-5138
Product Specifications
Product Name Alternative
SC 0030
UNSPSC Description
NV-5138, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 is used for antidepressant studies[1][2].
Target Antigen
mTOR
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nv-5138.html
Purity
98.0
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
N[C@@H](CC(C)(C(F)F)C)C(O)=O
Molecular Weight
181.182
References & Citations
[1]Sengupta S, et al. Discovery of NV-5138, the first selective Brain mTORC1 activator. Sci Rep. 2019 Mar 11;9(1):4107.|[2]Kato T, et al. Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation. J Clin Invest. 2019 Apr 16;129(6):2542-2554.Cell Metab. 2024 Jun 18:S1550-4131(24)00189-X.|bioRxiv. 2023 Apr 24.|biorxiv. 2024 May 27.|McGill University. 2023 Jul 5.|Neuron. 2023 Oct 4;111(19):3028-3040.e6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-114384/NV-5138-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-114384/NV-5138-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
2095886-80-7
Available Sizes
Curated Selection
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