SynuClean-D

SynuClean-D (SC-D) is an inhibitor of α-synuclein aggregation, disrupts mature amyloid fibrils, prevents fibril propagation, and abolishes the degeneration of dopaminergic neurons in an animal model of Parkinson’s disease[1].

Product Specifications

CAS Number

[685121-45-3]

Product Name Alternative

SC-D

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

α-synuclein

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/synuclean-d.html

Concentration

10mM

Purity

99.89

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

N#CC1=C(C(F)(F)F)C([N+]([O-])=O)=C(C2=CC=CC([N+]([O-])=O)=C2)NC1=O

Molecular Formula

C13H5F3N4O5

Molecular Weight

354.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Pujols J, et al. Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons. Proc Natl Acad Sci U S A. 2018 Oct 9;115 (41) :10481-10486.