ATX-0126

ATX-0126 (ATX 100) is an ionizable lipid based on thiocarbamate. ATX-0126 can be involved in the formation of lipid nanoparticles and is used in research such as nucleic acid delivery[1][2].

Product Specifications

CAS Number

[2230647-37-5]

Product Name Alternative

ATX 100

UNSPSC

12352211

Hazard Statement

H302, H315, H319

Target

Biochemical Assay Reagents; Liposome

Type

Oligonucleotides

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/mrna-encapsulating-lipid-excipient-1.html

Purity

99.94

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 20 mg/mL (ultrasonic)

Smiles

O=C(N(CCCC(OC(CCCCCCC)CCCCCCC)=O)CCCC(OC(CCCCCCC)CCCCCCC)=O)SCCCN(C)C

Molecular Formula

C44H86N2O5S

Molecular Weight

755.23

Precautions

H302, H315, H319

References & Citations

[1]Kumar Rajappan, et al. Development of a Safe and Scalable Process for the Production of a High-Purity Thiocarbamate-Based Ionizable Lipid as an Excipient in mRNA-Encapsulating Lipid Nanoparticles. Org. Process Res. Dev. 2021, 25, 6, 1383-1390.|[2]Preparation of ionizable cationic lipids for RNA delivery. US20180170866A1