RO5454948

RO5454948 (Compound 9) is the inhibitor for Dyrk1B and Dyrk1A with IC50 of 68 nM and 22 nM. RO5454948 exhibits cytotoxicity in cancer cell SW620 with EC50 of 1.9 μM[1][2].

Product Specifications

CAS Number

[1386979-55-0]

Product Name Alternative

Mirk-IN-1; Dyrk1B/A-IN-1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DYRK

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ro5454948.html

Purity

99.53

Solubility

DMSO : 2 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

ClC1=CC=C(C(NCC2=CC(Cl)=CC=C2)=O)C=C1NC(C3=CC4=CN=C(OC)N=C4N=C3O)=O

Molecular Formula

C23H17Cl2N5O4

Molecular Weight

498.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Ewton DZ, et al. Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells. Mol Cancer Ther. 2011 Nov;10 (11) :2104-14.|[2]Anderson K, et al. Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23 (24) :6610-5.|[3]Deng X, et al., Mirk kinase inhibition blocks the in vivo growth of pancreatic cancer cells. Genes Cancer. 2014 Sep;5 (9-10) :337-47.