3′,4′,7-Trihydroxyflavone

3′,4′,7-Trihydroxyflavone is an orally active inhibitor of OXA-48 (IC50 = 1.89 μM) and COX-1 (IC50 = 36.37 μM) . 3′,4′,7-Trihydroxyflavone exhibits antioxidant and anti-inflammatory properties, inhibiting the release of inflammatory cytokines such as IL-6, IL-8, and TNF-α. 3′,4′,7-Trihydroxyflavone inhibits H2O2-induced neuronal apoptosis and ROS accumulation, and exerts anti-neuroinflammatory effects by suppressing the JNK-STAT1 pathway. 3′,4′,7-Trihydroxyflavone exhibits antimicrobial and antibiotic-modifying activities against multidrug-resistant Gram-negative enteric bacteria. 3′,4′,7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1. 3′,4′,7-Trihydroxyflavone activates the CREB-BDNF axis and restores scopolamine (HY-N0296) -induced memory deficits in mice[1][2][3][4][5][6][7][8][9].

Product Specifications

CAS Number

[2150-11-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Akt; Apoptosis; Bacterial; Bcl-2 Family; Beta-lactamase; Caspase; COX; ERK; Interleukin Related; JNK; Lactate Dehydrogenase; NO Synthase; Nuclear Factor of activated T Cells (NFAT) ; p38 MAPK; Reactive Oxygen Species (ROS) ; SOD; STAT

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/3-4-7-trihydroxyflavone.html

Purity

98.0

Solubility

DMSO : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=CC=C(O)C=C2OC(C3=CC(O)=C(O)C=C3)=C1

Molecular Formula

C15H10O5

Molecular Weight

270.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Kim SS, et al. 3',4',7-trihydroxyflavone activates the CREB-BDNF axis and restores scopolamine-induced memory deficit in mice. Eur J Pharmacol. 2025 Jul 15;999:177645|[2]Codo Toafode NM, et al. Anti-Inflammatory Potential of Phenolic Compounds Isolated From Entada africana Guill. & Perr. Used in the Republic of Benin. Front Pharmacol. 2022 Jun 30;13:931240.|[3]Zhang Y, et al. Discovery of Quercetin and Its Analogs as Potent OXA-48 Beta-Lactamase Inhibitors. Front Pharmacol. 2022 Jun 22;13:926104.|[4]Kwon SH, et al. 3',4',7-Trihydroxyflavone prevents apoptotic cell death in neuronal cells from hydrogen peroxide-induced oxidative stress. Food Chem Toxicol. 2015 Jun;80:41-51.|[5]Dzotam JK, et al. In vitro antibacterial and antibiotic modifying activity of crude extract, fractions and 3',4',7-trihydroxyflavone from Myristica fragrans Houtt against MDR Gram-negative enteric bacteria. BMC Complement Altern Med. 2018 Jan 15;18 (1) :15. |[6]Akaishi T, et al. 3',4',7-Trihydroxyflavone Downregulates NO Production in LPS- or IFN-γ-Activated MG6 Microglial Cells by Attenuating the JNK-STAT1 Pathway. Biol Pharm Bull. 2022;45 (3) :301-308.|[7]Kang JH, et al. 3'4'7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1. Pharmazie. 2015 Oct;70 (10) :661-7. |[8]Selvam C, et al. Cyclooxygenase inhibitory flavonoids from the stem bark of Semecarpus anacardium Linn. Phytother Res. 2004 Jul;18 (7) :582-4.|[9]Jung MJ, et al. Antioxidant activity from the stem bark of Albizzia julibrissin. Arch Pharm Res. 2003 Jun;26 (6) :458-62.