Suberic acid

Suberic acid (Octanedioic acid) is an orally active crystalline dibasic acid. Suberic acid activates the Akt signaling pathway and regulates the expression of molecules related to the TGF-β and MAPK signaling pathways. Suberic acid inhibits skin dryness[1][2].

Product Specifications

CAS Number

[505-48-6]

Product Name Alternative

Octanedioic acid

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Akt; Endogenous Metabolite; p38 MAPK; TGF-β Receptor

Type

Natural Products

Related Pathways

MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; TGF-beta/Smad

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Octanedioic_acid.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C(C(O)=O)CCCCCC(O)=O

Molecular Formula

C8H14O4

Molecular Weight

174.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Kang W, et al. Activation of OR10A3 by Suberic Acid Promotes Collagen Synthesis in UVB-Irradiated Dermal Fibroblasts via the cAMP-Akt Pathway. Cells. 2022 Dec 7;11 (24) :3961.|[2]Kang W, et al. Dietary Suberic Acid Protects Against UVB-Induced Skin Photoaging in Hairless Mice. Nutrients. 2019 Dec 4;11 (12) :2948.