BWX 46

BWX 46 (((Cys31, Nva 34) -Neuropeptide Y (27-36) ) 2) is a selective Y5 receptor agonist with an IC50 value of 0.85 nM. BWX 46 can inhibit the synthesis of cAMP in Y5 cells[1].

Product Specifications

CAS Number

[172997-92-1]

Product Name Alternative

((Cys31, Nva 34) -Neuropeptide Y (27-36) ) 2

UNSPSC

12352209

Target

Neuropeptide Y Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bwx-46.html

Solubility

10 mM in DMSO

Smiles

OC(C=C1)=CC=C1C[C@H](N)C(N[C@]([C@@H](C)CC)([H])C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CSSC[C@@H](C(N[C@]([C@H](O)C)([H])C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CC2=CC=C(O)C=C2)=O)=O)=O)=O)=O)NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@@]([C@@H](C)CC)([H])NC([C@@H](N)CC3=CC=C(O)C=C3)=O)=O)=O)=O)C(N[C@]([C@H](O)C)([H])C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CC4=CC=C(O)C=C4)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C116H186N36O28S2

Molecular Weight

2597.07

References & Citations

[1]Balasubramaniam A, et al. Bis (31/31') [[Cys (31), Nva (34) ]NPY (27-36) -NH (2) ]: a neuropeptide Y (NPY) Y (5) receptor selective agonist with a latent stimulatory effect on food intake in rats. Peptides. 2002;23 (8) :1485-1490.