DAPT (GMP)

DAPT (GSI-IX) (GMP) is DAPT (HY-13027) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DAPT is a potent and orally active γ-secretase inhibitor[1][2].

Product Specifications

CAS Number

[208255-80-5]

Product Name Alternative

GSI-IX (GMP)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

γ-secretase

Type

GMP Small Molecules

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dapt-gmp.html

Purity

99.3

Solubility

10 mM in DMSO

Smiles

FC1=CC(F)=CC(CC(N[C@H](C(N[C@H](C(OC(C)(C)C)=O)C2=CC=CC=C2)=O)C)=O)=C1

Molecular Formula

C23H26F2N2O4

Molecular Weight

432.46

Precautions

H302, H315, H319, H335

References & Citations

[1]Choi IY, et al. Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model. Cell Rep. 2016 Jun 7;15 (10) :2301-2312.|[2]Qi Y, et al. Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells. Nat Biotechnol. 2017 Feb;35 (2) :154-163.