AS1517499
AS1517499 is a potent and brain-permeable STAT6 phosphorylation inhibitor with an IC50 of 21 nM.
Product Specifications
CAS Number
[919486-40-1]
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/AS1517499.html
Concentration
10mM
Purity
99.17
Solubility
DMSO : ≥ 35 mg/mL
Smiles
O=C(C1=CN=C(NCCC2=CC=C(O)C(Cl)=C2)N=C1NCC3=CC=CC=C3)N
Molecular Formula
C20H20ClN5O2
Molecular Weight
397.86
Precautions
H302, H312, H332
References & Citations
[1]Nagashima S, et al. Synthesis and evaluation of 2-{[2- (4-hydroxyphenyl) -ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors. Bioorg Med Chem. 2007 Jan 15;15 (2) :1044-55.|[2]Chiba Y, et al. A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice. Am J Respir Cell Mol Biol. 2009 Nov;41 (5) :516-24.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT6
Available Sizes
Curated Selection
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