Specnuezhenide

Specnuezhenide ((8E) -Nuezhenide) is isolated from the fruits of Ligustrum lucidum. Specnuezhenide ((8E) -Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E) -Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA) [1].

Product Specifications

CAS Number

[39011-92-2]

Product Name Alternative

(8E) -Nuezhenide

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NF-κB; Wnt

Type

Natural Products

Related Pathways

NF-κB; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/specnuezhenide.html

Purity

99.52

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

C/C=C([C@@H]1O[C@]([C@@H]([C@@H](O)[C@@H]2O)O)([H])O[C@@H]2CO)\[C@@H](C(C(OC)=O)=CO1)CC(OC[C@H]([C@H]([C@H](O)[C@H]3O)O)O[C@H]3OCCC4=CC=C(O)C=C4)=O

Molecular Formula

C31H42O17

Molecular Weight

686.66

Precautions

H302, H315, H319, H335

References & Citations

[1]Ma C, et al. Specnuezhenide Decreases Interleukin-1β-Induced Inflammation in Rat Chondrocytes and Reduces Joint Destruction in Osteoarthritic Rats.Front Pharmacol. 2018 Jun 28;9:700.|[2]Wu J, et al. Inhibition of Hypoxia-Induced Retinal Angiogenesis by Specnuezhenide, an Effective Constituent of Ligustrum lucidum Ait., through Suppression of the HIF-1α/VEGF Signaling Pathway.Molecules. 2016 Dec 21;21 (12) . pii: E1756.