3-(2-Hydroxyethyl) thio withaferin A
Product Specifications
UNSPSC Description
3-(2-Hydroxyethyl) thio withaferin A is a Withaferin A derivative. Withaferin A, a steroidal lactone, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding[1][2][3].
Target Antigen
NF-κB
Type
Natural Products
Related Pathways
NF-κB
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/3-2-hydroxyethyl-thio-withaferin-a.html
Solubility
10 mM in DMSO
Smiles
C[C@H](C1OC(C(CO)=C(C)C1)=O)C2CCC3C4C[C@@H]5[C@]([C@@]6(C)C4CC[C@@]32C)(O5)[C@@H](O)[C@@H](SCCO)CC6=O
Molecular Weight
548.73
References & Citations
[1]Kaileh M, et al. Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity. J Biol Chem. 2007 Feb 16;282(7):4253-64. Epub 2006 Dec 6.|[2]Bargagna-Mohan P, et al. The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin. Chem Biol. 2007 Jun;14(6):623-34.|[3]Kakar SS, et al. Withaferin A (WFA) inhibits tumor growth and metastasis by targeting ovarian cancer stem cells. Oncotarget. 2017 Aug 10;8(43):74494-74505.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N10358/3-2-Hydroxyethyl-thio-withaferin-A-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N10358/
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS2065081-01 0.1 mL
PE-Linked Polyclonal Antibody to Calcium Modulating Ligand (CAMLG)
Ask
View Details MBS2065081-02 0.2 mL
PE-Linked Polyclonal Antibody to Calcium Modulating Ligand (CAMLG)
Ask
View Details MBS2065081-03 0.5 mL
PE-Linked Polyclonal Antibody to Calcium Modulating Ligand (CAMLG)
Ask
View Details MBS2065081-04 1 mL
PE-Linked Polyclonal Antibody to Calcium Modulating Ligand (CAMLG)
Ask
View Details