LASSBio-873

LASSBio-873 is an orally active muscarinic cholinergic receptor (mAChR) agonist that crosses the blood-brain barrier. LASSBio-873 has potent analgesic effects on acute and inflammatory pain. The analgesic effect of LASSBio-873 can be inhibited by intrathecal injection of the M2 receptor antagonist methoctramine[1].

Product Specifications

CAS Number

[873694-54-3]

UNSPSC

12352005

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lassbio-873.html

Purity

99.82

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1N(C2=CC=C([N+]([O-])=O)C=C2)C(C3=C1C=NC4=C3C(C)=NN4C5=CC=CC=C5)=O

Molecular Formula

C21H13N5O4

Molecular Weight

399.36

References & Citations

[1]Mendes TC, et al. Antihyperalgesic effects of a novel muscarinic agonist (LASSBio-873) in spinal nerve ligation in rats. Clin Exp Pharmacol Physiol. 2013 Jul;40 (7) :404-11.