Thiocolchicine

Thiocolchicine, a derivative modified in the C Ring of Colchicine (HY-16569) with enhanced biological properties. Thiocolchicine is a potent inhibitor of tubulin polymerization (IC50=2.5 μM) and competitively binds to tubulin with a Ki of 0.7 μM. Thiocolchicine induces cell apoptosis[1][2]. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.

Product Specifications

CAS Number

[2730-71-4]

Product Name Alternative

(±)-4-Hydroxy Propranolol-d16,(±)-4-Hydroxy Propranolol-d7 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H300+H330-H318-H340

Target

Apoptosis; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thiocolchicine.html

Purity

99.77

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(N[C@H](C1=C2)CCC3=CC(OC)=C(OC)C(OC)=C3C1=CC=C(SC)C2=O)=O

Molecular Formula

C22H25NO5S

Molecular Weight

415.50

Precautions

P260-P264-P270-P271-P280-P284-P304+P340-P305+P351+P338-P330-P403+P233-P405-P501

References & Citations

[1]Klaus M.Hahn, et al. Structural requirements for the binding of colchicine analogs to tubulin: the role of the C-10 substituent. Bioorganic & Medicinal Chemistry Letters.Volume 1, Issue 9, 1991, Pages 471-476|[2]R De Vincenzo, et al. Antiproliferative Activity of Colchicine Analogues on MDR-positive and MDR-negative Human Cancer Cell Lines. Anticancer Drug Des. 1998 Jan;13 (1) :19-33.