RWJ52353

RWJ52353 is a selective, orally active ligand for α2D adrenoceptor, which binds α2D, α2A, α2B and α1 receptors, with Kis of 1.5, 254, 621 and 443 nM. RWJ52353 exhibits analgesic efficacy in mouse abdominal irritation test (MAIT), with an ED50 of 15.1 mg/kg[1].

Product Specifications

CAS Number

[245744-10-9]

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rwj52353.html

Smiles

C1(C2=CCCC3=C2C=CS3)=CN=CN1

Molecular Formula

C11H10N2S

Molecular Weight

202.28

References & Citations

[1]Ross TM, et al., alpha (2) Adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4- (4-Imidazo) -1,3-dimethyl-6,7-dihydrothianaphthene [corrected] as a high-affinity ligand for the alpha (2D) adrenergic receptor. J Med Chem. 2000 Mar 9;43 (5) :765-8.