Xanthosine

Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine activates the AMPK/FoxO1/AKT/GSK3β signaling cascade. Xanthosine promotes cell proliferation and regulates blood glucose metabolism. Xanthosine increases milk production in cows and goats. Xanthosine is used in mammary stem cell and type 2 diabetes research[1][2][3][4][5][6].

Product Specifications

CAS Number

[146-80-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/9-__2R,3R,4S,5R_-3,4-Dihydroxy-5-_hydroxymethyl_tetrahydrofuran-2-yl_-9H-purine-2,6-diol.html

Purity

99.99

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(NC3=O)=O)=C3N=C2)O1

Molecular Formula

C10H12N4O6

Molecular Weight

284.23

Precautions

H302, H315, H319

References & Citations

[1]Choudhary S, et, al. Examination of the xanthosine response on gene expression of mammary epithelial cells using RNA-seq technology. J Anim Sci Technol. 2018 Jul 13;60:18.|[2]Choudhary RK, et al. In vitro expansion of the mammary stem/progenitor cell population by xanthosine treatment. BMC Cell Biol. 2012 Jun 14;13:14.|[3]Rauner G, et al. Xanthosine administration does not affect the proportion of epithelial stem cells in bovine mammary tissue, but has a latent negative effect on cell proliferation. Exp Cell Res. 2014 Oct 15;328 (1) :186-196.|[4]Ahmed SA, et al. Xanthosine, a purine glycoside mediates hepatic glucose homeostasis through inhibition of gluconeogenesis and activation of glycogenesis via regulating the AMPK/ FoxO1/AKT/GSK3β signaling cascade. Chem Biol Interact. 2023 Feb 1;371:110347. |[5]MOULTON, et al. Histamine release and pain production by xanthosine and related compounds. Br J Pharmacol Chemother. 1957 Sep;12 (3) :365-70.|[6]Capuco AV, et al. In vivo expansion of the mammary stem/ progenitor cell population by xanthosine infusion. Exp Biol Med (Maywood) . 2009 Apr;234 (4) :475-82.