GW0072

GW0072 is a partial agonist of PPARγ and does not directly bind to the AF-2 helix of PPARγ, resulting in specific partial receptor transcriptional activation properties[1][2].

Product Specifications

CAS Number

[321557-86-2]

UNSPSC

12352005

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/gw0072.html

Smiles

O=C(C1=CC=C(C=C1)CCCCN2[C@@H](S[C@H](C2=O)CC(N(CC3=CC=CC=C3)CC4=CC=CC=C4)=O)CCCCCCC)O

Molecular Formula

C37H46N2O4S

Molecular Weight

614.84

References & Citations

[1]Ligand entry pathways in the ligand binding domain of PPARc receptor|[2]Genest D, et al. Ligand-escape pathways from the ligand-binding domain of PPARgamma receptor as probed by molecular dynamics simulations. Eur Biophys J. 2008 Apr;37 (4) :369-79. |[3]Zhang F, et al. Selective Modulators of PPAR-gamma Activity: Molecular Aspects Related to Obesity and Side-Effects. PPAR Res. 2007;2007:32696.