Hydroxyflutamide

Hydroxyflutamide (HFT) is the active metabolite of Flutamide (HY-B0022) and exhibits oral activity. Hydroxyflutamide is a potent androgen receptor antagonist with an IC50 of 700 nM. Hydroxyflutamide can affect embryonic development and reproductive tract development in mice. Additionally, Hydroxyflutamide can enhance the efficacy of Bacillus Calmette-Guérin (BCG) to better inhibit the progression of bladder cancer. Hydroxyflutamide can be used in research related to tumors and reproductive diseases[1][2][3][4][5].

Product Specifications

CAS Number

[52806-53-8]

Product Name Alternative

HFT

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Akt; Androgen Receptor; Drug Metabolite; Gap Junction Protein; Integrin; PI3K

Type

Reference compound

Related Pathways

Cytoskeleton; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hydroxyflutamide.html

Purity

99.90

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)(O)C(NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1)=O

Molecular Formula

C11H11F3N2O4

Molecular Weight

292.21

Precautions

H315, H319, H335

References & Citations

[1]Furr BJ, et, al. Casodex: preclinical studies and controversies. Ann N Y Acad Sci. 1995 Jun 12;761:79-96. |[2]Yallampalli C, et al. Influence of the anti-androgen hydroxyflutamide on in vitro development of mouse embryos. J Reprod Fertil. 1993 Nov;99 (2) :467-70.|[3]Shang Z, et al. Antiandrogen Therapy with Hydroxyflutamide or Androgen Receptor Degradation Enhancer ASC-J9 Enhances BCG Efficacy to Better Suppress Bladder Cancer Progression. Mol Cancer Ther. 2015 Nov;14 (11) :2586-94.|[4]Chojnacka K, et al. Hydroxyflutamide affects connexin 43 via the activation of PI3K/Akt-dependent pathway but has no effect on the crosstalk between PI3K/Akt and ERK1/2 pathways at the Raf-1 kinase level in primary rat Sertoli cells. Toxicol In Vitro. 2016 Mar;31:146-57.|[5]Silversides DW, et al. Effects of short-term exposure to hydroxyflutamide in utero on the development of the reproductive tract in male mice. Can J Physiol Pharmacol. 1995 Nov;73 (11) :1582-8.