PAR4 antagonist 7
Product Specifications
UNSPSC Description
PAR4 antagonist 7 (Compound 20f) is selective PAR4 antagonist (IC50: 1.72 nM). PAR4 antagonist 7 inhibits PAR4 agonist-induced platelet aggregation. PAR4 antagonist 7 has good metabolic stability. PAR4 antagonist 7 does not show a bleeding tendency in mice[1].
Target Antigen
Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/par4-antagonist-7.html
Smiles
COC1=NC2=CC(C)=CC(C3=NC4=C(S3)C(C[C@@H](O5)COC(NC6=CC=CC(C#N)=C6)=O)=C5C(F)=C4)=C2C=N1
Molecular Weight
541.55
References & Citations
[1]Li S, et al. Discovery of quinazoline-benzothiazole derivatives as novel potent protease-activated receptor 4 antagonists with improved pharmacokinetics and low bleeding liability. Eur J Med Chem. 2024 Dec 15;280:116980.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-159895/PAR4-antagonist-7-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-159895/
Clinical Information
No Development Reported
Curated Selection
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