U-14624
U-14624 is a potent and orally active dopamine beta-hydroxylase inhibitor. U-14624 suppresses the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes[1][2].
Product Specifications
CAS Number
[14901-16-7]
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Dopamine β-hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/u-14624.html
Purity
99.67
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
S=C(NC1=CC=CC=C1)NC2=NC=CS2
Molecular Formula
C10H9N3S2
Molecular Weight
235.33
Precautions
H302, H312, H332
References & Citations
[1]Von Voigtlander PF, et al. Behavioral and brain catecholamine depleting actions of U-14,624, an inhibitor of dopamine beta-hydroxylase. Proc Soc Exp Biol Med. 1970 Mar;133 (3) :817-20.|[2]Smith JR, et al. Effect of the catecholamine-depleting agent 1-phenyl-3- (2-thiazolyl) -2-thiourea (U-14,624) on drug metabolism in the rat. Biochem Pharmacol. 1980 Sep 15;29 (18) :2425-30.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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