CP-99994 (hydrochloride)
Product Specifications
UNSPSC Description
CP-99994 hydrochloride is a high-affinity NK1 antagonist that exhibits the biological activity of preventing colorectal sensitization in the context of visceral hypersensitivity. CP-99994 hydrochloride reduces colorectal hypersensitivity induced by acetic acid injections in a model of bladder-colon cross-sensitization. CP-99994 hydrochloride attenuates the neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity.
Target Antigen
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cp-99994-hydrochloride.html
Smiles
COC(C=CC=C1)=C1CN[C@@H]2[C@H](C3=CC=CC=C3)NCCC2.Cl.Cl
Molecular Weight
369.33
References & Citations
[1]Bladder-colon chronic cross-sensitization involves neuro-glial pathways in male mice
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12145/CP-99994-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12145/
Clinical Information
No Development Reported
CAS Number
145148-39-6
Curated Selection
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