GSK121
GSK121 is a selective PAD4 inhibitor. GSK121 can be used in the research of PAD4-related diseases, including those characterized by abnormal NET levels and various tumors[1][2][3].
Product Specifications
CAS Number
[1652591-80-4]
Product Name Alternative
CGS 10746
UNSPSC
12352005
Target
Protein Arginine Deiminase
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gsk121.html
Purity
99.50
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1CCCN(C1)C(C2=CC3=C(C=C2)N(C)C(C4=CC5=C(N4C)C=CC=C5)=N3)=O.OC(C(F)(F)F)=O
Molecular Formula
C25H26F3N5O3
Molecular Weight
501.50
References & Citations
[1]Drewes G, et al. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nat Chem Biol. 2015 Mar;11 (3) :189-91.|[2]Iaia S. Protein Arginine Deiminases: a novel mechanism of leukocyte trafficking under physiological and pathological conditions[J]. 2021.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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