Bisdemethoxycurcumin-d8

Bisdemethoxycurcumin-d8 (Curcumin III-d8) is the deuterium labeled Bisdemethoxycurcumin (HY-N0007A) . Bisdemethoxycucurmin (Curcumin III) is a curcuminoid compound and an inhibitor of P-glycoprotein and ferroptosis. Bisdemethoxycucurmin exhibits multiple activities such as anti-oxidation, anti-inflammation and anti-tumor. Bisdemethoxycucurmin can be used for the research of tumors and inflammatory diseases[1][2][3][4][5].

Product Specifications

CAS Number

[2470233-08-8]

Product Name Alternative

Curcumin III-d8; Didemethoxycurcumin-d8

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

DNA/RNA Synthesis; Ferroptosis; Isotope-Labeled Compounds; P-glycoprotein

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Others

Field of Research

Cancer; Inflammation/Immunology

Purity

98.0

Solubility

10 mM in DMSO|DMSO : ≥ 100mg/mL

Smiles

O=C(CC(/C=C/C1=C([2H])C([2H])=C(O)C([2H])=C1[2H])=O)/C=C/C2=C([2H])C([2H])=C(O)C([2H])=C2[2H]

Molecular Formula

C19H8D8O4

Molecular Weight

316.38

Precautions

H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Lee PJ, et al. Bisdemethoxycurcumin Induces Apoptosis in Activated Hepatic Stellate Cells via Cannabinoid Receptor 2. Molecules. 2015 Jan 14;20 (1) :1277-92.|[3]Chen J, et al. Natural borneol enhances bisdemethoxycurcumin-induced cell cycle arrest in the G2/M phase through up-regulation of intracellular ROS in HepG2 cells. Food Funct. 2014 Dec 24.|[4]Luo C, et al. Bisdemethoxycurcumin attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction. Oncol Lett. 2015 Jan;9 (1) :270-274.|[5]Li YB, et al. Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells. Evid Based Complement Alternat Med. 2013;2013:851714.