Exo2

Exo2 is a secretion inhibitor. Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network. Exo2 blocks secretory cargo exit from the ER (endoplasmic reticulum) and disrupts the Golgi apparatus, but does not affect the morphology of the TGN (trans-Golgi network) Exo2 can stimulate calcium-dependent exocytosis in permeabilized adrenal chromaff in cells[1][2].

Product Specifications

CAS Number

[304684-77-3]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/exo2.html

Concentration

10mM

Purity

99.57

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC(C=C(C=C1)/C=N/NC2=C3C(CCCC4)=C4SC3=NC=N2)=C1O

Molecular Formula

C18H18N4O2S

Molecular Weight

354.43

Precautions

H302, H312, H332

References & Citations

[1]Spooner RA, et al. The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network. Biochem J. 2008 Sep 15;414 (3) :471-84.|[2]Morgan A, et al. Exo1 and Exo2 proteins stimulate calcium-dependent exocytosis in permeabilized adrenal chromaffin cells. Nature. 1992 Feb 27;355 (6363) :833-6.