Emidurdar

Endovion is a pharmacological anion channel inhibitor (like chloride channel) and the specific VRAC/VSOAC blocker. Endovion (NS3728) is also an Anoctamin-1 (ANO 1) channel inhibitor[1][2].

Product Specifications

CAS Number

[265646-85-3]

Product Name Alternative

Endovion; NS3728

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Chloride Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/emidurdar.html

Concentration

10mM

Purity

99.41

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

FC(F)(F)C1=CC(C(F)(F)F)=CC(NC(NC2=C(C3=NN=NN3)C=C(Br)C=C2)=O)=C1

Molecular Formula

C16H9BrF6N6O

Molecular Weight

495.18

Precautions

H315, H319

References & Citations

[1]Sørensen BH, et al. Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against CDDP-induced expression of p53, MDM2, p21Waf1/Cip1, and Caspase-9/-3 activation. Am J Physiol Cell Physiol. 2016 Jun 1;310 (11) :C857-73.|[2]Sauter DR, et al. ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC) . Pflugers Arch. 2015 Jul;467 (7) :1495-1508.