Recombinant Human TYK2/JTK1 Protein (GST Tag, Active)

<strong>Recombinant Human TYK2/JTK1 Protein (GST Tag, Active)</strong>_x000D_ <strong>Catalog number:</strong> B2019012_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 5 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> ~110 kDa_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> −80°C_x000D_ <strong>Keywords:</strong> IMD35 Protein, Human; JTK1 Protein, Human_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Dendrou CA, Cortes A, Shipman L, Evans HG, Attfield KE, Jostins L, Barber T, Kaur G, Kuttikkatte SB, Leach OA, Desel C, Faergeman SL, Cheeseman J, Neville MJ, Sawcer S, Compston A, Johnson AR, Everett C, Bell JI, Karpe F, Ultsch M, Eigenbrot C, McVean G, Fugger L. Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity Sci Transl Med. 2016 Nov 2;8(363):363ra149._x000D_ 2: Boisson-Dupuis S. The monogenic basis of human tuberculosis Hum Genet. 2020 Jun;139(6-7):1001-1009._x000D_ 3: Yang Z, Xiang Q, Nicholas J. Direct and biologically significant interactions of human herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus kinase TYK2 PLoS Pathog. 2023 Nov 20;19(11):e1011806._x000D_ 4: Barbieri G, Velazquez L, Scrobogna M, Fellous M, Pellegrini S. Activation of the protein tyrosine kinase tyk2 by interferon alpha/beta Eur J Biochem. 1994 Jul 15;223(2):427-35._x000D_ 5: Lukashova V, Asselin C, Krolewski JJ, Rola-Pleszczynski M, Stanková J. G-protein-independent activation of Tyk2 by the platelet-activating factor receptor J Biol Chem. 2001 Jun 29;276(26):24113-21._x000D_ 6: Velazquez L, Mogensen KE, Barbieri G, Fellous M, Uzé G, Pellegrini S. Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon-alpha/beta and for signal transduction J Biol Chem. 1995 Feb 17;270(7):3327-34._x000D_ 7: Nagano Y, Sugiyama A, Kimoto M, Wakahara T, Noguchi Y, Jiang X, Saijo S, Shimizu N, Yabuno N, Yao M, Gooley PR, Moseley GW, Tadokoro T, Maenaka K, Ose T. The Measles Virus V Protein Binding Site to STAT2 Overlaps That of IRF9 J Virol. 2020 Aug 17;94(17):e01169-20._x000D_ 8: Vainchenker W, Dusa A, Constantinescu SN. JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies Semin Cell Dev Biol. 2008 Aug;19(4):385-93._x000D_ 9: Chivero ET, Bhattarai N, McLinden JH, Xiang J, Stapleton JT. Human Pegivirus (HPgV; formerly known as GBV-C) inhibits IL-12 dependent natural killer cell function Virology. 2015 Nov;485:116-27._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/25349176">10: Velusamy T, Kiel MJ, Sahasrabuddhe AA, Rolland D, Dixon CA, Bailey NG, Betz BL, Brown NA, Hristov AC, Wilcox RA, Miranda RN, Medeiros LJ, Jeon YK, Inamdar KV, Lim MS, Elenitoba-Johnson KS. A novel recurrent NPM1-TYK2 gene fusion in cutaneous CD30-positive lymphoproliferative disorders Blood. 2014 Dec 11;124(25):3768-71. </a>_x000D_ _x000D_ <strong>Products Related to Recombinant Human TYK2/JTK1 Protein (GST Tag, Active) can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>