ML-211

ML-211 is a carbamate-based dual inhibitor of acyl-protein thioesterase 1 (APT1) /lysophospholipase 1 (LYPLA1) (IC50=17 nM) and LYPLA2 (IC50=30 nM) . ML-211 also inhibits theserine hydrolase ABHD11 with an IC50 value of 10 nM but is ≥ 50-fold selective for LYPLA in a panel of 20 additional serine hydrolases[1].

Product Specifications

CAS Number

[2205032-89-7]

UNSPSC

12352005

Target

MAGL; Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ml-211.html

Purity

99.42

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1CCC(C(C)(C)C)CC1)N2N=CC(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)=N2

Molecular Formula

C25H30N4O2

Molecular Weight

418.53

References & Citations

[1]Adibekian, A., Martin, B.R., Speers, A.E., et al. Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2) . Probe Reports from the NIH Molecular Libraries Program 1 R01 CA132630, 1-42 (2013) .