Ginsenoside Rh4

Ginsenoside Rh4 is a rare saponin obtained from Panax notoginseng. Ginsenoside Rh4 activates Bax, caspase 3, caspase 8, and caspase 9. Ginsenoside Rh4 also induces autophagy.

Product Specifications

CAS Number

[174721-08-5]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Autophagy; Bcl-2 Family; Caspase; Endogenous Metabolite

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Ginsenoside-Rh4.html

Purity

99.28

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@]12[C@@](C[C@H]([C@@]3([H])[C@]2(CC[C@@H]3/C(C)=C/C/C=C(C)\C)C)O)([H])[C@@]4([C@@](C(C)([C@H](CC4)O)C)([H])[C@H](C1)O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO)C

Molecular Formula

C36H60O8

Molecular Weight

620.86

Precautions

H302

References & Citations

[1]Wu Q, et al. Ginsenoside Rh4 induces apoptosis and autophagic cell death through activation of the ROS/JNK/p53 pathway in colorectal cancer cells. Biochem Pharmacol. 2018 Feb;148:64-74.