Cymarin

Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX) -induced K+ release (IC50=0.42 μM) . Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer. Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant[1][2][3][4].

Product Specifications

CAS Number

[508-77-0]

UNSPSC

12352005

Hazard Statement

H301+H331, H373

Target

Parasite; Potassium Channel

Type

Natural Products

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Field of Research

Cancer; Others

Assay Protocol

https://www.medchemexpress.com/cymarin.html

Purity

97.82

Solubility

10 mM in DMSO

Smiles

O=C[C@@]12[C@]3([H])[C@](CC[C@@]1(C[C@@H](O[C@@]4([H])C[C@@H]([C@H](O)[C@@H](C)O4)OC)CC2)O)([H])[C@@]5([C@@](C)([C@@H](C(CO6)=CC6=O)CC5)CC3)O

Molecular Formula

C30H44O9

Molecular Weight

548.66

Precautions

H301+H331, H373

References & Citations

[1]Ozaki H, et al. Interaction of palytoxin and cardiac glycosides on erythrocyte membrane and (Na+ + K+) ATPase. Eur J Biochem. 1985;152 (2) :475-480. |[2]Li Q, et al., Translation of paired box 6 (PAX6) mRNA is IRES-mediated and inhibited by cymarin in breast cancer cells. Genes Genet Syst. 2023 Oct 24;98 (4) :161-169.|[3]Akhtar Y, et al., Comparative growth inhibitory and antifeedant effects of plant extracts and pure allelochemicals on four phytophagous insect species. J Applied Entomology. 10 February 2004.128,32-38.|[4]Tan L, et al., A targetable pathway to eliminate TRA-1-60+/TRA-1-81+ chemoresistant cancer cells. J Mol Cell Biol. 2023 Nov 27;15 (6) :mjad039.