Exisulind
Exisulind is an inactive metabolite of the nonsteroidal, anti-inflammatory agent sulindac[1]. Exisulind inhibits aldose reductase with an IC50 of 367 nM in vitro and may contribute to the beneficial pharmacological effects of sulindac on type 2 diabetic complications[2].
Product Specifications
CAS Number
[59864-04-9]
UNSPSC
12352005
Target
Aldose Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/exisulind.html
Concentration
10mM
Purity
98.04
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)CC(C1=C/2C=CC(F)=C1)=C(C)C2=C/C3=CC=C(S(=O)(C)=O)C=C3
Molecular Formula
C20H17FO4S
Molecular Weight
372.41
References & Citations
[1]Kitamura S, Tatsumi K. In vitro metabolism of sulindac and sulindac sulfide: enzymatic formation of sulfoxide and sulfone. Jpn J Pharmacol. 1982 Oct;32 (5) :833-8.|[2]Zheng X, et al. The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase. FEBS Lett. 2012 Jan 2;586 (1) :55-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
Curated Selection
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