ACE2 Rabbit pAb

Angiotensin I converting enzyme 2 (ACE2) Homo sapiens The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.

Product Specifications

Background

Product Name Alternative

Angiotensin-converting enzyme 2 (EC 3.4.17.23) (ACE-related carboxypeptidase) (Angiotensin-converting enzyme homolog) (ACEH) (Metalloprotease MPROT15) [Cleaved into: Processed angiotensin-converting enzyme 2]

UniProt

Q9BYF1

Swiss Prot

Q9BYF1

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from human ACE2 AA range: 425-475

Target

ACE2

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; WB

Concentration

1 mg/ml

Dilution

IHC-p1:50-200 , WB 1:1000-2000

Buffer

-20°C/1 year

Molecular Weight

120-135kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

120-135kD

Fragment

IgG

Subcellular Location

[Processed angiotensin-converting enzyme 2]: Secreted .; Cell membrane ; Single-pass type I membrane protein . Cytoplasm . Cell projection, cilium . Apical cell membrane . Detected in both cell membrane and cytoplasm in neurons. .; [Isoform 2]: Apical cell membrane .