α-Phellandrene

α-Phellandrene (alpha-Phellandrene) is an orally active monoterpenoid and insecticide. α-Phellandrene can be isolated from plant essential oils. α-Phellandrene induces Apoptosis and Autophagy. α-Phellandrene promotes cAMP signaling pathway and increases NO production. α-Phellandrene has anti-inflammatory and anticancer (sarcoma) activities. α-Phellandrene shows insecticidal activity against Lucilia cuprina L3. α-Phellandrene reduces mechanical hyperalgesia[1][2][3][4][5][6][7][8][9][10][11].

Product Specifications

CAS Number

[99-83-2]

Product Name Alternative

Alpha-Phellandrene

UNSPSC

12352211

Hazard Statement

H226, H302, H315, H319, H334, H335

Target

Apoptosis; Autophagy; Insecticide; NO Synthase

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Immunology/Inflammation; Others

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/α-phellandrene.html

Concentration

10mM

Purity

86.66

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

CC1=CCC(C=C1)C(C)C

Molecular Formula

C10H16

Molecular Weight

136.23

Precautions

H226, H302, H315, H319, H334, H335

References & Citations

[1]Abdouli I, et al. TiO2 Catalyzed Dihydroxyacetone (DHA) Conversion in Water: Evidence That This Model Reaction Probes Basicity in Addition to Acidity. Molecules. 2022 Nov 24;27 (23) :8172.|[2]Susanto AC, et al. α‑Phellandrene enhances the apoptosis of HT‑29 cells induced by 5‑fluorouracil by modulating the mitochondria‑dependent pathway. Oncol Rep. 2024 Apr;51 (4) :61.|[3]Hsieh SL, et al. Induction of necrosis in human liver tumor cells by α-phellandrene. Nutr Cancer. 2014;66 (6) :970-9.|[4]Lin JJ, et al. α-Phellandrene alters expression of genes associated with DNA damage, cell cycle, and apoptosis in murine leukemia WEHI-3 cells. Anticancer Res. 2014 Aug;34 (8) :4161-80. |[5]Kang W, et al. Activation of cAMP Signaling in Response to α-Phellandrene Promotes Vascular Endothelial Growth Factor Levels and Proliferation in Human Dermal Papilla Cells. Int J Mol Sci. 2022 Aug 11;23 (16) :8959.|[6]Hsieh LC, et al. Induction of α-phellandrene on autophagy in human liver tumor cells. Am J Chin Med. 2015;43 (1) :121-36.|[7]Chaaban A, et al. Insecticide activity of Curcuma longa (leaves) essential oil and its major compound α-phellandrene against Lucilia cuprina larvae (Diptera: Calliphoridae) : Histological and ultrastructural biomarkers assessment. Pestic Biochem Physiol. 2019 Jan;153:17-27.|[8]Lin JJ, et al. Alpha-phellandrene promotes immune responses in normal mice through enhancing macrophage phagocytosis and natural killer cell activities. In Vivo. 2013 Nov-Dec;27 (6) :809-14. |[9]Pinheiro-Neto FR, et al. α-Phellandrene exhibits antinociceptive and tumor-reducing effects in a mouse model of oncologic pain. Toxicol Appl Pharmacol. 2021 May 1;418:115497. |[10]Gonçalves R L G, et al. α-Phellandrene attenuates tissular damage, oxidative stress, and TNF-α levels on acute model ifosfamide-induced hemorrhagic cystitis in mice. Naunyn-Schmiedeberg's Archives of Pharmacology, 2020, 393: 1835-1848.|[11]Siqueira HDS, et al. α-Phellandrene, a cyclic monoterpene, attenuates inflammatory response through neutrophil migration inhibition and mast cell degranulation. Life Sci. 2016 Sep 1;160:27-33.