Biricodar

Biricodar (VX-710) is a modulator of P-glycoprotein and MRP-1; shows effective chemosensitizing activity in multidrug resistant cells.

Product Specifications

CAS Number

[159997-94-1]

Product Name Alternative

VX-710

UNSPSC

12352005

Target

P-glycoprotein

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Biricodar.html

Purity

99.31

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C([C@H]1N(C(C(C2=CC(OC)=C(OC)C(OC)=C2)=O)=O)CCCC1)OC(CCCC3=CC=CN=C3)CCCC4=CC=CN=C4

Molecular Formula

C34H41N3O7

Molecular Weight

603.71

References & Citations

[1]Minderman H, et al. VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein. Clin Cancer Res. 2004 Mar 1;10 (5) :1826-34.|[2]Yanagisawa T, et al. BIRICODAR (VX-710; Incel) : an effective chemosensitizer in neuroblastoma. Br J Cancer. 1999 Jun;80 (8) :1190-6.|[3]Germann UA, et al. Cellular and biochemical characterization of VX-710 as a chemosensitizer: reversal of P-glycoprotein-mediated multidrug resistance in vitro. Anticancer Drugs. 1997 Feb;8 (2) :125-40.