M-3M3FBS

M-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis[1][2][3].

Product Specifications

CAS Number

[200933-14-8]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Phospholipase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/m-3m3fbs.html

Concentration

10mM

Purity

99.99

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(C1=C(C)C=C(C)C=C1C)(NC2=CC=CC(C(F)(F)F)=C2)=O

Molecular Formula

C16H16F3NO2S

Molecular Weight

343.36

Precautions

H315, H319, H335

References & Citations

[1]Bae YS, et al. Identification of a compound that directly stimulates phospholipase C activity. Mol Pharmacol. 2003;63 (5) :1043-1050.|[2]Krjukova J, et al. Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation. Br J Pharmacol. 2004;143 (1) :3-7.|[3]Lee YN, et al. The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis. Cancer Lett. 2005;222 (2) :227-235.