6-O-Isobutyrylbritannilactone
Product Specifications
UNSPSC Description
6-O-Isobutyrylbritannilactone is a natural melanogenesis inhibitor. 6-O-Isobutyrylbritannilactone, a sesquiterpene, can be isolated from the flowers of Inula britannica. 6-O-Isobutyrylbritannilactone inhibits IBMX (HY-12318)-induced melanin production in B16F10 cells. 6-O-Isobutyrylbritannilactone also regulates ERK, PI3K/AKT, and CREB, shows antimelanogenic activity in zebrafish embryos models[1].
Target Antigen
Akt; Epigenetic Reader Domain; ERK; PI3K
Type
Natural Products
Related Pathways
Epigenetics;MAPK/ERK Pathway;PI3K/Akt/mTOR;Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/6-o-isobutyrylbritannilactone.html
Solubility
10 mM in DMSO
Smiles
CC(C)C(O[C@H]1[C@@]2([H])[C@@](OC(C2=C)=O)([H])CC(C)=C1[C@@H](C)CCCO)=O
Molecular Weight
336.42
References & Citations
[1]Jang DK, et al. Anti-Melanogenesis Activity of 6-O-Isobutyrylbritannilactone from Inula britannica on B16F10 Melanocytes and In Vivo Zebrafish Models. Molecules. 2020 Aug 26;25(17):3887.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N10802/6-O-Isobutyrylbritannilactone-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N10802/
Clinical Information
No Development Reported
CAS Number
1259933-02-2
Curated Selection
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