Cassiaside

Cassiaside is a naphthopyrone glucoside, shows mixed-type inhibition against BACE1 (IC50=4.45 μM; Ki=9.85 μM) . Cassiaside possesses potential anti- Alzheimer's disease (AD) activity[1].

Product Specifications

CAS Number

[13709-03-0]

UNSPSC

12352005

Target

Beta-secretase

Type

Natural Products

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cassiaside.html

Purity

99.67

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC1=C(C2=O)C(OC(C)=C2)=CC3=C1C(O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]([C@H]4O)CO)=CC(O)=C3

Molecular Formula

C20H20O10

Molecular Weight

420.37

References & Citations

[1]Jung HA, et al. Inhibitory activities of major anthraquinones and other constituents from Cassia obtusifolia against β-secretase and cholinesterases. J Ethnopharmacol. 2016;191:152-160.