Exicorilant

Exicorilant (CORT 125281) is a selective and oral active glucocorticoid receptor (GR) antagonist, with a Ki value of 7 nM[1]. Exicorilant (CORT 125281) has potential to overcome adiposity, glucose intolerance and dyslipidaemia[2].

Product Specifications

CAS Number

[1781244-77-6]

Product Name Alternative

CORT 125281

UNSPSC

12352005

Target

Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/exicorilant.html

Purity

99.48

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C([C@]12CC3=C(N(C4=CC=C(F)C=C4)N=C3)C[C@]1([H])CCN(S(=O)(C5=NN(C)N=C5)=O)C2)C6=NC=CC(C(F)(F)F)=C6

Molecular Formula

C26H23F4N7O3S

Molecular Weight

589.56

References & Citations

[1]Hunt HJ, et al. Identification of the Clinical Candidate (R) - (1- (4-Fluorophenyl) -6- ((1-methyl-1H-pyrazol-4-yl) sulfonyl) -4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl) (4- (trifluoromethyl) pyridin-2-yl) methanone (CORT125134) : A Selective Glucocorticoid Receptor (GR) Antagonist. J Med Chem. 2017 Apr 27;60 (8) :3405-3421.|[2]Kroon J, et al. Selective Glucocorticoid Receptor Antagonist CORT125281 Activates Brown Adipose Tissue and Alters Lipid Distribution in Male Mice. Endocrinology. 2018 Jan 1;159 (1) :535-546.